Meenal is currently working as a Senior Research Fellow (SRF) in the group. Her main area of research is particle manipulation, concentration and collection using non-uniform AC electric fields. More specifically, her work on gold nanoparticles entails using an interplay of electrohydrodynamic (EHD) and dielectrophoretic (DEP) forces to create assemblies that can transition from one-dimensional (1D) microwires to 2D thin films by merely tuning the operating experimental conditions.(1) The structures obtained can potentially have applications in biosensing or microelectronics.
Using the same microelectrode platform, Meenal has also developed a nifty protocol where she can collect live bacterial cells onto designated areas on a chip and simultaneously study their antimicrobial susceptibility behavior.(2) The results are truly very exciting since the cell death can be probed as early as within an hour of drug incubation, unlike the overnight methods typically used during cell plating.
In her third slightly unrelated project, Meenal is developing a novel approach for separating and simultaneously detecting binary mixtures of proteins in real-time inside microfluidic chips. For this, she uses a surface-immobilized resin matrix to separate proteins and standard curves prepared using surface plasmon resonance (SPR) spectroscopy to give the composition of the unknown sample.
- Goel M., Singh S., Bhola A. and Gupta S., ‘Tunable assembly of gold nanoparticles using a combination of electrohydrodynamic and dielectrophoretic forces’ Under preparation
- Dixit A., Goel M. and Gupta S., ‘Optimization of optoelectronically tunable CdTe microwire formation using AC dielectrophoresis’, Submitted
- Goel M., Verma A. and Gupta S., ‘Electric-field driven capture and detection of live bacterial cells in microarrays‘, Biosensors and Bioelectronics, 11, 159 – 165 (2018)